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Article

Mutational alterations in the QRDR regions associated with fluoroquinolone resistance in Pseudomonas aeruginosa of clinical origin from Savar, Dhaka.

PloS one - 1 Jan 2025

Arefin Md Shamsul, Mitu Meftahul Jannat, Mitu Shomaia Yasmin, Nurjahan Azmery, Mobin Mir, Nahar Shamsun, Anjum Hasnain, Rahman M Hasibur

Abstract excerpt

Bacterial DNA gyrase and topoisomerase IV are the major targets of quinolone antibiotic, and mutational alterations in quinolone resistance determining regions (QRDR) serve as major mechanism of resistance in most bacterial species, including P. aeruginosa. The present investigation was aimed to study the molecular mechanism of fluoroquinolone resistance among clinical P. aeruginosa isolated from Dhaka,...

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PMID: 39993019
DOI: 10.1371/journal.pone.0302352
PMCID: PMC12002805

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