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The Effect of HLA Polymorphism on Immune Response to SARS-CoV-2 Vaccination Within an Infection-Naïve, Vulnerable Population With End-Stage Renal Disease.

HLA - 1 Feb 2025

Erskine Fiona, Spensley Katrina, Prendecki Maria, Santos Eva, Anand Arthi, Altmann Danny, Willicombe Michelle

Abstract excerpt

HLA genes exhibit a high degree of polymorphism, contributing to genetic variability known to influence immune responses to infection. Here we investigate associations between HLA polymorphism and serological and T-lymphocyte responses to the BNT162b2 and ChAdOx1 SARS-CoV-2 vaccines within a population receiving maintenance haemodialysis (HD) for End-Stage Renal Disease (ESRD). Our primary objective was to...

Read the complete abstract on PubMed

Topics

Humans
Kidney Failure, Chronic
COVID-19
SARS-CoV-2
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

BNT162 Vaccine

Aged

Polymorphism, Genetic

Antibodies, Viral

HLA Antigens

COVID-19 Vaccines

Renal Dialysis

Adult

T-Lymphocytes

Alleles

ChAdOx1 nCoV-19

Source

Open in PubMed Open full text

Identifiers

PMID: 39991976
DOI: 10.1111/tan.70076
PMCID: PMC11848999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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