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Amniotic fluid-derived exosomal miR-146a-5p ameliorates preeclampsia phenotypes by inhibiting HIF-1α/FLT-1 expression.

Placenta - 25 Mar 2025

Lin Jin, Huang Xiaohong, Zhang Jing, Yang Weiming, Sun Fan, Huang Bo, Lu Wan, Wang Xiaozhong

Abstract excerpt

INTRODUCTION: Preeclampsia (PE) is a pregnancy-specific complication that begins with hypertension and proteinuria and seriously threatens the health of pregnant women and fetuses. Abnormal expression of amniotic fluid-derived exosomal miR-146a-5p was observed in PE. However, the role of human amniotic fluid-derived exosomes (AF-Exos) and miR-146a-5p in PE remains unclear. METHODS: We determined the miR-146a-5p...

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PMID: 39987849
DOI: 10.1016/j.placenta.2025.02.013

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