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Article

Predicting immunotherapy response of advanced bladder cancer through a meta-analysis of six independent cohorts.

Nature communications - 20 Feb 2025

Boll Lilian Marie, Vázquez Montes de Oca Sergio, Camarena Marta E, Castelo Robert, Bellmunt Joaquim, Perera-Bel Júlia, Albà M Mar

Abstract excerpt

Advanced bladder cancer patients show very variable responses to immune checkpoint inhibitors (ICIs) and effective strategies to predict response are still lacking. Here we integrate mutation and gene expression data from 707 advanced bladder cancer patients treated with anti-PD-1/anti-PD-L1 to build highly accurate predictive models. We find that, in addition to tumor mutational burden (TMB), enrichment in the...

Read the complete abstract on PubMed

Topics

Humans
B7-H1 Antigen
Cohort Studies
Immune Checkpoint Inhibitors
Immunotherapy
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Programmed Cell Death 1 Receptor

Treatment Outcome

Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 39979258
DOI: 10.1038/s41467-025-56462-0
PMCID: PMC11842772

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