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Intraneoplastic fungal dysbiosis is associated with colorectal cancer progression and host gene mutation

17 Feb 2025

Abstract excerpt

BACKGROUND: The relationship between intraneoplastic fungi and colorectal cancer (CRC) progression remains largely unclear. Here, we investigated fungal community changes in adenoma and CRC and their correlation with host genetic mutations. METHODS: We obtained 261 tissue biopsies from two geographically distinct cohorts of CRC and adenoma patients, with each individual contributing 2-5 biopsies from lesions and...

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PMID: 39970705
DOI: 10.1016/j.ebiom.2025.105608

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