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Article

Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy.

Nature - 1 Mar 2025

Falcucci Lara, Dooley Christopher M, Adamoski Douglas, Juan Thomas, Martinez Justin, Georgieva Angelina M, Mamchaoui Kamel, Cirzi Cansu, Stainier Didier Y R

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a muscle-degenerating disease caused by mutations in the DMD gene, which encodes the dystrophin protein1,2. Utrophin (UTRN), the genetic and functional paralogue of DMD, is upregulated in some DMD patients3-5. To further investigate this UTRN upregulation, we first developed an inducible messenger RNA (mRNA) degradation system for DMD by introducing a premature termination...

Topics

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Dystrophin
Muscle Fibers, Skeletal
Muscular Dystrophy, Duchenne
Nonsense Mediated mRNA Decay
Oligonucleotides, Antisense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39939773
DOI: 10.1038/s41586-024-08539-x
PMCID: PMC11903304

Genes

DMD
UTRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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