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Article

Efficient Modulation of Exon Skipping via Antisense Circular RNAs

1 Jan 2023

Abstract excerpt

Splice-switching antisense oligonucleotides (ASOs) and engineered U7 small nuclear ribonucleoprotein (U7 Sm OPT) are the most commonly used methods for exon skipping. However, challenges remain, such as limited organ delivery and repeated dosing for ASOs and unknown risks of by-products produced by U7 Sm OPT. Here, we showed that antisense circular RNAs (AS-circRNAs) can effectively mediate exon skipping in both...

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PMID: 37040525
DOI: 10.34133/research.0045

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