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Article

A Cascaded Chip for the High-Purity Capture and Distinguishing Detection of Phenotypic Circulating Tumor Cells in Colon Cancer.

Analytical chemistry - 25 Feb 2025

Liu Tingting, Zhang Wenmeng, Zhang Yin, Liu Yuping, Gao Shuai, Zuo Yingchun, Zhu Liang, Li Chenglin, Yu Yanyan

Abstract excerpt

The low abundance, complex phenotypes, and need for sophisticated blood preprocessing pose substantial obstacles to the clinical implementation of circulating tumor cells (CTCs). Herein, we constructed a cascaded PMMA chip-based platform for the separation of CTCs from other cells within blood samples, as well as distinguishing the detection of epithelial and mesenchymal CTCs. The primary physical separation chip...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39933075
DOI: 10.1021/acs.analchem.4c05517

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