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CDK16 + Luminal Progenitor Cell‐Like Tumor Cells Interacted with POSTN + Cancer‐Associated Fibroblasts Associate with Chemo‐Resistance In Breast Cancer

10 Feb 2025

Abstract excerpt

Abstract Tumor heterogeneity and interaction with tumor microenvironment play a crucial role in neoadjuvant chemotherapy (NAC) resistance in breast cancer (BRCA). Unraveling this dynamic interaction may help uncover novel therapeutic targets. Here, dynamic changes in tumor states and cellular composition are systemically characterized using 175,825 single‐cell transcriptomics from naïve and post‐treatment...

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PMID: 39930931
DOI: 10.1002/smtd.202401192

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