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Article

Evolutionary rescue of bacterial populations by heterozygosity on multicopy plasmids.

Journal of mathematical biology - 6 Feb 2025

Dewan Ian, Uecker Hildegard

Abstract excerpt

Bacterial plasmids and other extrachromosomal DNA elements frequently carry genes with important fitness effects for their hosts. Multicopy plasmids can additionally carry distinct alleles of host-fitness-relevant genes on different plasmid copies, allowing for heterozygosity not possible for loci on haploid chromosomes. Plasmid-mediated heterozygosity may increase the fitness of bacterial cells in circumstances...

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Identifiers

PMID: 39909926
DOI: 10.1007/s00285-025-02182-4
PMCID: PMC11799102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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