Genome-Wide Association Study on Muscle Stiffness Identified Novel Locus for Predisposition to Muscle Strain Injury.

doi:10.1249/MSS.0000000000003661

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Genome-Wide Association Study on Muscle Stiffness Identified Novel Locus for Predisposition to Muscle Strain Injury.

Medicine and science in sports and exercise - 1 Jun 2025

Miyamoto-Mikami Eri, Zempo Hirofumi, Kumagai Hiroshi, Hirata Kosuke, Takaragawa Mizuki, Yoshihara Toshinori, Fuku Mizuho, Kikuchi Naoki, Kamiya Nobuhiro, Miyamoto Naokazu, Fuku Noriyuki

Abstract excerpt

PURPOSE: We aimed to screen the entire genome for genetic variants associated with passive muscle stiffness, which has been suggested as a risk factor for muscle strain injury. METHODS: This genome-wide association study (GWAS) on passive muscle stiffness included 350 physically active young Japanese individuals. Three hamstring constituents were measured using ultrasound shear wave elastography. Skeletal muscle...

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Topics

Humans
Genome-Wide Association Study
Male
Female
Young Adult
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sprains and Strains

Hamstring Muscles

Polymorphism, Single Nucleotide

Chromosomes, Human, Pair 11

Elasticity Imaging Techniques

Adult

Athletic Injuries

Muscle, Skeletal

Genetic Loci

Transcriptome

Genotype

Source

Open in PubMed

Identifiers

PMID: 39902889
DOI: 10.1249/MSS.0000000000003661

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