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Article

Early total care and damage control orthopaedics result in partially contrasting patterns of microRNA expression at the fracture site and in the systemic circulation

1 Feb 2025

Abstract excerpt

Aims: The aims of this study, using a porcine model of multiple trauma, were to investigate the expression of microRNAs at the fracture site, in the fracture haematoma (fxH) and in the fractured bone, compared with a remote unfractured long bone, to characterize the patterns of expression of circulating microRNAs in plasma, and identify and validate messenger RNA (mRNA) targets of the microRNAs. Methods: Two...

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PMID: 39889739
DOI: 10.1302/0301-620x.107b2.bjj-2024-0160.r3

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