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Article

Genomic Analysis Reveals Racial and Age-Related Differences in the Somatic Landscape of Breast Cancer and the Association with Socioeconomic Factors.

Cancer research - 3 Apr 2025

Van Alsten Sarah C, Love Michael I, Calhoun Benjamin C, Butler Eboneé N, Perou Charles M, Hoadley Katherine A, Troester Melissa A

Abstract excerpt

Cancer genomics consortia have identified somatic drivers of breast cancer subtypes. However, these studies have predominantly included older, non-Black women, and the related socioeconomic status (SES) data are limited. Increased representation and depth of social data are crucial for understanding how health inequity is intertwined with somatic landscapes. Here, we conducted targeted sequencing on primary...

Read the complete abstract on PubMed

Topics

Humans
Female
Breast Neoplasms
Middle Aged
Mutation
Genomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Copy Number Variations

Adult

Aged

Socioeconomic Factors

Black or African American

Age Factors

Biomarkers, Tumor

White

Source

Open in PubMed Open full text

Identifiers

PMID: 39879109
DOI: 10.1158/0008-5472.CAN-24-1788
PMCID: PMC12034101

Genes

PIK3CA
CDH1
GATA3
TP53
DDR2
FAT1
KMT2C
MAP3K1
MYC
PTEN

Provenance

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