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Article

LncRNA SNHG5 induces CAFs-like phenotype and autophagy of AML-MSCs via PTBP1/ATG5 axis to confer chemoresistance of AML cells.

Cellular signalling - 1 Apr 2025

Song Yuan, Hu Lili, Cheng Jing, Li Zhenjiang, Zheng Jifu

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is still a threaten to human health due to its high occurrence and poor prognosis. Mesenchymal stem cells (MSCs) in bone marrow microenvironment (BMM) play a critical role in the development of AML. This study elucidated the interaction between MSCs and AML cells and its underlying mechanism. METHOD: MSCs were isolated, identified, and co-cultured with AML cells. qRT-PCR,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39864537
DOI: 10.1016/j.cellsig.2025.111625

Genes

ATG5
PTBP1
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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