Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Local cortical structure pattern and genetic links in schizophrenia: An MRI and CRISPR/Cas9 study.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Mar 2025

Hou Pei-Shan, Lin Shu-Fei, Zhu Jun-Ding, Chung Chih-Yun, Tsai Shih-Jen, Yang Albert C

Abstract excerpt

While the etiology of schizophrenia (SZ) remains elusive, its diverse phenotypes suggest the involvement of distinct functional cortical areas, and the heritability of SZ implies the underlying genetic factors. This study aimed to integrate imaging and molecular analyses to elucidate the genetic underpinnings of SZ. We investigated the local cortical structural pattern changes in Brodmann areas (BAs) by...

Topics

Join the communities discussing this publication.

Cerebral Cortex
CRISPR-Cas Systems
Genome-Wide Association Study
Magnetic Resonance Imaging
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39862915
DOI: 10.1016/j.pnpbp.2025.111270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Local cortical structure pattern and genetic links in schizophrenia: An MRI and CRISPR/Cas9 study.PMID 39862915Read ↗

Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia.Semantic proximity Read ↗

Molecular and micro-architectural mapping of gray matter alterations in psychosisSemantic proximity Read ↗

The genetic architecture of the human cerebral cortex.Semantic proximity Read ↗

Individual Brain Structure Deviations and its Gene Expression Signatures in Early-Onset SchizophreniaSemantic proximity Read ↗

The genetic architecture of the human cerebral cortexSemantic proximity Read ↗

Cortical differences across psychiatric disorders and associated common and rare genetic variantsSemantic proximity Read ↗

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortexSemantic proximity Read ↗

The variegation of human brain vulnerability to rare genetic disorders and convergence with behaviorally defined disordersSemantic proximity Read ↗

Transcriptional patterns of the cortical Morphometric Inverse Divergence in first-episode, treatment-naïve early-onset schizophreniaSemantic proximity Read ↗

The genetic relationships between brain structure and schizophrenia.Semantic proximity Read ↗

Morphometric Analysis of Structural MRI Using Schizophrenia Meta-analytic Priors Distinguish Patients from Controls in Two Independent Samples and in a Sample of Individuals With High Polygenic Risk.Semantic proximity Read ↗

A pattern of continuity from health to disease in neuropsychiatric genetic risk affecting brain morphologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.