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Article

GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway

24 Jan 2025

Abstract excerpt

BACKGROUND: Ovarian cancer (OC) progression is one of the commonest cause of female cancer death. While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly improved. Thus, further investigation of the mechanisms regarding OC carcinogenesis and discovery of novel targets is of great importance. METHODS: Human ovarian tissue specimens,...

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PMID: 39856733
DOI: 10.1186/s13046-025-03275-0

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