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Article

Natural Killer Cell Education in Women With Recurrent Pregnancy Loss.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Feb 2025

Lombardi Amber E M, Habets Denise H J, Al-Nasiry Salwan, Spaanderman Marc E A, Wieten Lotte

Abstract excerpt

PROBLEM: Natural killer (NK) cells undergo education for full functionality via interactions between killer immunoglobulin-like receptors (KIRs) or NKG2A and human leukocyte antigen (HLA) ligands. Presumably, education is important during early pregnancy as insufficient education has been associated with impaired vascular remodeling and restricted fetal growth in mice. NK cell education is influenced by receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39853841
DOI: 10.1111/aji.70045
PMCID: PMC11760664

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