Article
Pharmacogenetic markers and macrolide safety in influenza patients: insights from a prospective study.
Pharmacogenomics - 1 Jan 2024
Skryabina A A, Nikiforov V V, Shakhmardanov M Z, Zastrozhin M S, Sychev D A
Abstract excerpt
BACKGROUND: Macrolides are widely used antibiotics, but adverse drug reactions (ADRs), particularly in genetically predisposed individuals, can compromise their safety. This study examines the impact of pharmacogenetic markers on macrolide safety in participants with bacterial complications of influenza. OBJECTIVE: To evaluate how polymorphisms in genes encoding transporter proteins (ABCB1) and enzymes (CYP3A4,...
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