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Article

DEAD/DEAH-box RNA helicases shape the risk of neurodevelopmental disorders.

Trends in genetics : TIG - 1 May 2025

Fiorenzani Chiara, Mossa Adele, De Rubeis Silvia

Abstract excerpt

The DEAD/DEAH-box family of RNA helicases (RHs) is among the most abundant and conserved in eukaryotes. These proteins catalyze the remodeling of RNAs to regulate their splicing, stability, localization, and translation. Rare genetic variants in DEAD/DEAH-box proteins have recently emerged as being associated with neurodevelopmental disorders (NDDs). Analyses in cellular and animal models have uncovered...

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Identifiers

PMID: 39828505
DOI: 10.1016/j.tig.2024.12.006
PMCID: PMC12055483

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