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NOTCH1 regulates the DNA damage response and sorafenib resistance by activating ATM in hepatocellular carcinoma

1 Jan 2024

Abstract excerpt

OBJECTIVE: This study investigates the mechanism underlying sorafenib resistance in hepatocellular carcinoma cells (HCC), focusing on DNA damage repair (DDR) pathways to develop targeted therapeutic strategies. METHODS: Bioinformatics analysis was used to screen genes associated with sorafenib resistance, which was further demonstrated by western blotting. Cell proliferation was determined using the EdU assay....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39822534
DOI: 10.62347/eafu3015

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