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Article

Multiple mutations in polyketide synthase led to disruption of Psittacofulvin production across diverse parrot species.

Communications biology - 17 Jan 2025

Ghosh Roy Shatadru, Brejcha Jindřich, Maršík Petr, Bakhrat Anna, Abdu Moty, Arbore Roberto, Araújo Pedro Miguel, Afonso Sandra, Carneiro Miguel, Grossman-Haham Iris, Abdu Uri

Abstract excerpt

Polyketide synthases (PKSs) are crucial multidomain enzymes in diverse natural product biosynthesis. Parrots use a type I PKS to produce a unique pigment called psittacofulvin in their feathers. In domesticated budgerigars and lovebirds, the same amino acid substitution (R644W) within malonyl/acetyltransferase (MAT) domain of this enzyme has been shown to cause the blue phenotype with no psittacofulvin...

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Identifiers

PMID: 39820005
DOI: 10.1038/s42003-025-07537-7
PMCID: PMC11739604

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