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Article

Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer.

Annals of medicine - 1 Dec 2025

Yu Yu-Zhong, Xie Xiao, Cai Mao-Ping, Hong Ya-Ying, Ren Yang-Zi, Kang Xi, Yan Hai-Chen, Xiong Yang, Chen Hong, Wu Xing-Cheng, Luo Dao-Sheng, Zhao Shan-Chao

Abstract excerpt

BACKGROUND: We previously described the enrichment of plasma exosome metabolites in CRPC, PCa, and TFC cohorts, and found significant differences in pyrimidine metabolites. The PMGs is associated with the clinical prognosis of several cancers, but its biological role in PCa is still unclear. METHODS: This study extracted 98 reliable PMGs, and analyzed their somatic mutations, expression levels, and prognostic...

Read the complete abstract on PubMed

Topics

Humans
Male
Prognosis
Prostatic Neoplasms
Pyrimidines
Thymidine Kinase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers, Tumor

Mutation

Tumor Microenvironment

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 39803822
DOI: 10.1080/07853890.2025.2449584
PMCID: PMC11731156

Genes

TK1
BCR

Provenance

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