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Article

Ancestral exposure to stress epigenetically programs preterm birth risk and adverse maternal and newborn outcomes

6 Aug 2014

Abstract excerpt

BACKGROUND: Chronic stress is considered to be one of many causes of human preterm birth (PTB), but no direct evidence has yet been provided. Here we show in rats that stress across generations has downstream effects on endocrine, metabolic and behavioural manifestations of PTB possibly via microRNA (miRNA) regulation. METHODS: Pregnant dams of the parental generation were exposed to stress from gestational days...

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Share to Maternal Mental Health During Pregnancy and Postpartum
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PMID: 25286408
DOI: 10.1186/s12916-014-0121-6

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