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Beyond the Hayflick limit: How microbes influence cellular aging

7 Jan 2025

Abstract excerpt

Cellular senescence, a complex biological process resulting in permanent cell-cycle arrest, is central to aging and age-related diseases. A key concept in understanding cellular senescence is the Hayflick Limit, which refers to the limited capacity of normal human cells to divide, after which they become senescent. Senescent cells (SC) accumulate with age, releasing pro-inflammatory and tissue-remodeling factors...

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PMID: 39788433
DOI: 10.1016/j.arr.2025.102657

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