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Comparative analysis of EGFR mutations in circulating tumor DNA and primary tumor tissues from lung cancer patients using BEAMing PCR.

Scientific reports - 8 Jan 2025

Mirikar Duhita, Banerjee Nandini, Prabhash Kumar, Kaushal Rajiv Kumar, Naronha Vanita, Pramesh C S, Karimundackal George, Joshi Amit, Rane Swapnil, Basak Ranjan

Abstract excerpt

In this study, we measured human epidermal growth factor receptor (EGFR) mutations in both tissue and circulating tumor DNA (ctDNA) by using beads, emulsions, amplifications and magnetic polymerase chain reaction (BEAMing PCR). Noninvasive mutation detection by assessing circulating tumor DNA (ctDNA) offers many advantages over tumor biopsy. One hundred non-small cell lung cancer (NSCLC) patients were enrolled,...

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Identifiers

PMID: 39775010
DOI: 10.1038/s41598-025-85160-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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