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Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

7 Jan 2025

Abstract excerpt

The continuing emergence of immune evasive SARS-CoV-2 variants and the previous SARS-CoV-1 outbreak collectively underscore the need for broadly protective sarbecovirus vaccines. Targeting the conserved S2 subunit of SARS-CoV-2 is a particularly promising approach to elicit broad protection. Here, we describe a nanoparticle vaccine displaying multiple copies of the SARS-CoV-1 S2 subunit. This vaccine alone, or as...

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PMID: 39774966
DOI: 10.1038/s41467-025-55824-y

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