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Article

X-Chromosome–Linked miRNAs Regulate Sex Differences in Cardiac Physiology

30 Dec 2024

Abstract excerpt

BACKGROUND: Males and females exhibit distinct anatomic and functional characteristics of the heart, predisposing them to specific disease states. METHODS: We identified microRNAs (miRNAs/miR) with sex-differential expression in mouse hearts. RESULTS: Four conserved miRNAs are present in a single locus on the X-chromosome and are expressed at higher levels in females than males. We show miRNA, miR-871, is...

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PMID: 39772608
DOI: 10.1161/circresaha.124.325447

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