Article
Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing.
Nature genetics - 1 Jan 2025
Glaus Anna N, Brechet Marion, Swinnen Gwen, Lebeigle Ludivine, Iwaszkiewicz Justyna, Ambrosini Giovanna, Julca Irene, Zhang Jing, Roberts Robyn, Iseli Christian, Guex Nicolas, Jiménez-Gómez José, Glover Natasha, Martin Gregory B, Strickler Susan, Soyk Sebastian
Abstract excerpt
Crop genomes accumulate deleterious mutations-a phenomenon known as the cost of domestication. Precision genome editing has been proposed to eliminate such potentially harmful mutations; however, experimental demonstration is lacking. Here we identified a deleterious mutation in the tomato transcription factor SUPPRESSOR OF SP2 (SSP2), which became prevalent in the domesticated germplasm and diminished DNA...
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