Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Analysis of the molecular pathogenesis of hereditary protein C deficiency due to a p.Gly86Asp variant of the PROC gene].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Jul 2022

Jiang Shuting, Wang Huanhuan, Liu Meina, Yang Lihong, Jin Yanhui, Xie Haixiao, Xu Qiyu, Wang Mingshan

Abstract excerpt

OBJECTIVE: To explore the molecular pathogenesis of hereditary protein C (PC) deficiency due to a p.Gly86Asp variant of the PROC gene through in vitro expression experiment. METHODS: Wild type and Gly86Asp mutant expression plasmids of PC were constructed and respectively transfected into HEK 293FT cells. Total RNA was extracted from the transfected cells, and the expression of PROC gene was determined by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PC gene
Share to PROC gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Plasmids

Share to Protein C

Share to Protein C Deficiency

Source

Identifiers

PMID: 35810421
DOI: 10.3760/cma.j.cn511374-20210525-00440

Genes

PC
PROC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Analysis of the molecular pathogenesis of hereditary protein C deficiency due to a p.Gly86Asp variant of the PROC gene].PMID 35810421Read ↗

[Molecular Mechanism of Protein C Deficiency Caused by Mutations of PROC Gene N355S, G392E, T314A].Semantic proximity Read ↗

[Analysis of PROC gene variant in a Chinese pedigree affected with hereditary protein C deficiency].Semantic proximity Read ↗

[Phenotypic and genotypic analysis of a pedigree affected with hereditary protein C deficiency due to heterozygous deletional mutation of PROC gene].Semantic proximity Read ↗

[Analysis of phenotypes and genetic mutations in two pedigrees affected with hereditary protein C deficiency].Semantic proximity Read ↗

[Phenotypic and genotypic analysis of a pedigree affected with hereditary protein C deficiency].Semantic proximity Read ↗

Two heterozygous mutations associated with type I protein C deficiency in two Chinese independent families.Semantic proximity Read ↗

[Analysis of an hereditary protein C deficiency pedigree with compound heterozygous gene mutations].Semantic proximity Read ↗

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions.Semantic proximity Read ↗

[Clinical and genetic analysis of a rare fetus with Protein C deficiency due to compound heterozygous variants of PROC gene].Semantic proximity Read ↗

Severe protein C deficiency from compound heterozygous mutations in the PROC gene in two Korean adult patients.Semantic proximity Read ↗

Homozygous protein C deficiency with late onset venous thrombosis: identification and in vitro expression study of a novel Pro275Ser mutation.Semantic proximity Read ↗

Analysis of PROC mutations and clinical features in 22 unrelated families with inherited protein C deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.