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The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design

26 Dec 2024

Abstract excerpt

PARP (poly-ADP ribose polymerase) has received widespread attention in cancer treatment. Research has shown that PARP plays a crucial role in DNA damage repair and has become a popular target for drug design. Based on the mechanism of "synthetic lethality", multiple PARPis (PARP inhibitors) have been launched for the treatment of BRCA deficient tumors. For example, the approved PARPis have shown significant...

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PMID: 39723587
DOI: 10.1021/acs.jmedchem.4c02642

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