DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Despite treatment advances, the survival rates of high-risk NB patients remain low. This highlights the urgent need for a deeper understanding of the molecular mechanisms driving NB progression to support the development of new therapeutic strategies. In this study, we demonstrated that the reduced levels of DNAJC12, a protein involved in...

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• Cancer, Hypoxia, and Metabolism
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