Exploration of histone protein γ‐ H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma

Abstract excerpt

Abstract This study evaluates the H2AX/γ‐H2AX expression in soft tissue sarcomas (STS), its implications for biological behavior and immune environment, and its potential as a prognostic biomarker. RNA‐Seq data from 237 STS were obtained from The Cancer Genome Atlas project. Patients were stratified by H2AX mRNA expression using a survival‐associated cutoff. Differentially expressed genes and pathways as well as...

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