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Azadirachtin disrupts ecdysone signaling and alters sand fly immunity

20 Dec 2024

Abstract excerpt

BACKGROUND: Leishmaniasis is a group of neglected vector-borne diseases transmitted by phlebotomine sand flies. Leishmania parasites must overcome various defenses in the sand fly midgut, including the insects's immune response. Insect immunity is regulated by the ecdysone hormone, which binds to its nuclear receptor (EcR) and activates the transcription of genes involved in insect immunity. However, the role of...

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PMID: 39707409
DOI: 10.1186/s13071-024-06589-8

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