Article
Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins.
mBio - 5 Feb 2025
Ma Andrew Z, Yeo Yao Yu, Lee Jean F, Kim Colin M, Ezzatpour Shahrzad, Menchaca Carolina, Upadhye Viraj, Annand Edward J, Eden John-Sebastian, Plowright Raina K, Peel Alison J, Buchholz David W, Aguilar Hector C
Abstract excerpt
A novel Hendra virus (HeV) genotype (HeV genotype 2 [HeV-g2]) was recently isolated from a deceased horse, revealing high-sequence conservation and antigenic similarities with the prototypic strain, HeV-g1. As the receptor-binding (G) and fusion (F) glycoproteins of HeV are essential for mediating viral entry, functional characterization of emerging HeV genotypic variants is key to understanding viral entry...
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