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GATA1 activates HSD17B6 to improve efficiency of cisplatin in lung adenocarcinoma via DNA damage

18 Dec 2024

Abstract excerpt

Abstract Background Lung adenocarcinoma (LUAD) is the most common histological type of non-small cell lung cancer (NSCLC). Platinum-based chemotherapy, such as cisplatin chemotherapy, is the cornerstone of treatment for LUAD patients. Nevertheless, cisplatin resistance remains the key obstacle to LUAD treatment, for its mechanism has not been fully elucidated. Methods HSD17B6 mRNA expression data were accessed...

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PMID: 39695810
DOI: 10.1186/s41021-024-00321-9

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