Article
Redefining Therapeutic Approaches in Colorectal Cancer: Targeting Molecular Pathways and Overcoming Resistance.
International journal of molecular sciences - 21 Nov 2024
Duta-Ion Simona Gabriela, Juganaru Ioana Ruxandra, Hotinceanu Iulian Andrei, Dan Andra, Burtavel Livia Malina, Coman Madalin Codrut, Focsa Ina Ofelia, Zaruha Andra Giorgiana, Codreanu Patricia Christina, Bohiltea Laurentiu Camil, Radoi Viorica Elena
Abstract excerpt
Colorectal cancer (CRC) arises through a combination of genetic and epigenetic alterations that affect key pathways involved in tumor growth and progression. This review examines the major molecular pathways driving CRC, including Chromosomal Instability (CIN), Microsatellite Instability (MSI), and the CpG Island Methylator Phenotype (CIMP). Key mutations in genes such as APC, KRAS, NRAS, BRAF, and TP53 activate...
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