Article
Neuronal Progenitors Suffer Genotoxic Stress in the Drosophila Clock Mutant per0.
Cells - 23 Nov 2024
Colonna Romano Nunzia, Marchetti Marcella, Marangoni Anna, Leo Laura, Retrosi Diletta, Rosato Ezio, Fanti Laura
Abstract excerpt
The physiological role and the molecular architecture of the circadian clock in fully developed organisms are well established. Yet, we have a limited understanding of the function of the clock during ontogenesis. We have used a null mutant (per0) of the clock gene period (per) in Drosophila melanogaster to ask whether PER may play a role during normal brain development. In third-instar larvae, we have observed...
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