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Article

Haematological setpoints are a stable and patient-specific deep phenotype.

Nature - 1 Jan 2025

Foy Brody H, Petherbridge Rachel, Roth Maxwell T, Zhang Cindy, De Souza Daniel C, Mow Christopher, Patel Hasmukh R, Patel Chhaya H, Ho Samantha N, Lam Evie, Powe Camille E, Hasserjian Robert P, Karczewski Konrad J, Tozzo Veronica, Higgins John M

Abstract excerpt

The complete blood count (CBC) is an important screening tool for healthy adults and a common test at periodic exams. However, results are usually interpreted relative to one-size-fits-all reference intervals1,2, undermining the precision medicine goal to tailor care for patients on the basis of their unique characteristics3,4. Here we study thousands of diverse patients at an academic medical centre and show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39663453
DOI: 10.1038/s41586-024-08264-5
PMCID: PMC12085991

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