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Potential of gut microbiota metabolites in treating COPD: network pharmacology and Mendelian randomization approaches

25 Nov 2024

Abstract excerpt

Objective The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate the role and mechanisms of the gut microbiota and its metabolites in COPD through network pharmacology and Mendelian randomization approaches. Methods Employing network pharmacology, we identified the gut microbiota and its metabolites’ impact on...

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PMID: 39654679
DOI: 10.3389/fmicb.2024.1416651

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