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Article

Hsp90 and cochaperones have two genetically distinct roles in regulating eEF2 function.

PLoS genetics - 1 Dec 2024

Fulton Melody D, Yama Danielle J, Dahl Ella, Johnson Jill L

Abstract excerpt

Protein homeostasis relies on the accurate translation and folding of newly synthesized proteins. Eukaryotic elongation factor 2 (eEF2) promotes GTP-dependent translocation of the ribosome during translation. eEF2 folding was recently shown to be dependent on Hsp90 as well as the cochaperones Hgh1, Cns1, and Cpr7. We examined the requirement for Hsp90 and cochaperones more closely and found that Hsp90 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39652595
DOI: 10.1371/journal.pgen.1011508
PMCID: PMC11651573

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