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Article

Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation

1 Dec 2024

Abstract excerpt

In the process of cardiac fibrosis, the balance between the Wnt/β-catenin signalling pathway and Wnt inhibitory factor genes plays an important role. Secreted frizzled-related protein 3 (sFRP3), a Wnt inhibitory factor, has been linked to epigenetic mechanisms. However, the underlying role of epigenetic regulation of sFRP3, which is crucial in fibroblast proliferation and migration, in cardiac fibrosis have not...

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PMID: 39644393
DOI: 10.1007/s00018-024-05516-5

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