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Article

DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.

Cardiovascular toxicology - 1 Dec 2021

Xu Sheng-Song, Ding Ji-Fei, Shi Peng, Shi Kai-Hu, Tao Hui

Abstract excerpt

Novel insights into epigenetic control of cardiac fibrosis are now emerging. Cardiac fibroblasts (CFs) activation into myofibroblasts and the production of extracellular matrix (ECM) is the key to cardiac fibrosis development, but the specific mechanism is not fully understood. In the present study, we found that DNMT1 hypermethylation reduces the expression of microRNA-152-3p (miR-152-3p) and promotes...

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PMID: 34424481
DOI: 10.1007/s12012-021-09690-x

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