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Article

Integrative analysis of multi-omics data identified PLG as key gene related to Anoikis resistance and immune phenotypes in hepatocellular carcinoma.

Journal of translational medicine - 4 Dec 2024

Wang Xueyan, Gao Lei, Li Haiyuan, Ma Yanling, Wang Bofang, Gu Baohong, Li Xuemei, Xiang Lin, Bai Yuping, Ma Chenhui, Chen Hao

Abstract excerpt

PURPOSE: The extracellular matrix (ECM) plays a pivotal role in the initiation and progression of hepatocellular carcinoma (HCC) by facilitating the proliferation of HCC cells and enabling resistance to Anoikis. ECM also provide structural support that aids in the invasion of HCC cells, thereby influencing the tumor microenvironment. Due to genetic variations and molecular heterogeneity, significant challenges...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39633373
DOI: 10.1186/s12967-024-05858-5
PMCID: PMC11616313

Genes

PLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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