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New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B

29 Nov 2024

Abstract excerpt

ABSTRACT The polysaccharide (PS) capsule of Streptococcus pneumoniae (pneumococcus) is the immunodominant surface structure that shields the bacteria from the host immune system. Since the capsule is the primary target of currently available pneumococcal vaccines, anti-capsular antibodies are highly protective but serotype-specific. Pneumococci may evade host or vaccine-induced immunity as a result of variation...

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PMID: 39612217
DOI: 10.1128/spectrum.02443-24

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