Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine.

doi:10.1128/JCM.00228-18

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Article

Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine.

Journal of clinical microbiology - 1 Jul 2018

Lo Stephanie W, Gladstone Rebecca A, van Tonder Andries J, Hawkins Paulina A, Kwambana-Adams Brenda, Cornick Jennifer E, Madhi Shabir A, Nzenze Susan A, du Plessis Mignon, Kandasamy Rama, Carter Philip E, Eser Özgen Köseoglu, Ho Pak Leung, Elmdaghri Naima, Shakoor Sadia, Clarke Stuart C, Antonio Martin, Everett Dean B, von Gottberg Anne, Klugman Keith P, McGee Lesley, Breiman Robert F, Bentley Stephen D

Abstract excerpt

A newly recognized pneumococcal serotype, 35D, which differs from the 35B polysaccharide in structure and serology by not binding to factor serum 35a, was recently reported. The genetic basis for this distinctive serology is due to the presence of an inactivating mutation in wciG, which encodes an O-acetyltransferase responsible for O-acetylation of a galactofuranose. Here, we assessed the genomic data of a...

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PMID: 29720431
DOI: 10.1128/JCM.00228-18
PMCID: PMC6018339

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