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Article

Association between the CYP2B6 polymorphisms and nonnucleoside reverse transcriptase inhibitors drug-induced liver injury: a systematic review and meta-analysis.

Scientific reports - 27 Nov 2024

Chanhom Noppadol, Sonjan Janjira, Inchai Jarupat, Udomsinprasert Wanvisa, Chaikledkaew Usa, Suvichapanich Supharat, Mahasirimongkol Surakameth, Jittikoon Jiraphun

Abstract excerpt

Nevirapine (NVP) and Efavirenz (EFV) can cause antiretroviral drug-induced liver injury (ARVDILI). The objectives of this study were to summarize and analyze existing data on pharmacogenomics associated with nonnucleoside reverse transcriptase inhibitors drug-induced liver injury using systematic review and meta-analysis. This study systematically searched the relevant studies regarding pharmacogenes related to...

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Alkynes
Benzoxazines
Chemical and Drug Induced Liver Injury
Cyclopropanes
Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Reverse Transcriptase Inhibitors

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Identifiers

PMID: 39604537
DOI: 10.1038/s41598-024-79965-0
PMCID: PMC11603346

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