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β3‐Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta

27 Nov 2024

Abstract excerpt

ABSTRACT At different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia‐inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low‐oxygen environment, including the induction of specific enzymes related to glycolytic metabolism, erythropoiesis, angiogenesis,...

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PMID: 39604126
DOI: 10.1002/med.22092

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