Article
Analysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development.
Viruses - 23 Oct 2024
Klontz Erik H, Chowdhury Navid, Holbrook Nolan, Solomon Isaac H, Telford Sam R, Aliota Matthew T, Vogels Chantal B F, Grubaugh Nathan D, Helgager Jeffrey, Hughes Holly R, Velez Jason, Piantadosi Anne, Chiu Charles Y, Lemieux Jacob, Branda John A
Abstract excerpt
Powassan virus (POWV) is an emerging tick-borne virus that causes severe meningoencephalitis in the United States, Canada, and Russia. Serology is generally the preferred diagnostic modality, but PCR on cerebrospinal fluid, blood, or urine has an important role, particularly in immunocompromised patients who are unable to mount a serologic response. Although the perceived poor sensitivity of PCR in the general...
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