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Epigenetic dysregulation of H19/IGF2 in hepatic cells exposed to toxic metal mixtures in vitro

26 Nov 2024

Abstract excerpt

Exposure to mixtures of toxic metals is known to cause adverse health effects through epigenetic alterations. Here we aimed to examine the unexplored area of aberrant DNA methylation in the H19 / IGF2 domain following combined toxic metal exposure. An in vitro epigenotoxicity assay using the human normal liver epithelial cell line THLE-3 was conducted. When THLE-3 cells were exposed to specific concentrations of...

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PMID: 39592715
DOI: 10.1038/s41598-024-80142-6

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