Aggressive Lymphoma after CD19 CAR T-Cell Therapy.

doi:10.1056/NEJMoa2402730

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Article

Aggressive Lymphoma after CD19 CAR T-Cell Therapy.

The New England journal of medicine - 3 Oct 2024

Kobbe Guido, Brüggemann Monika, Baermann Ben-Niklas, Wiegand Laura, Trautmann Heiko, Yousefian Schayan, Libertini Silvana, Menssen Hans D, Maier Harald J, Ulrich Peter, Gao Jingbo, Bruch Peter-Martin, Liebers Nora, Radujkovic Aleksandar, Seifert Marc, Schniederjohann Christina, Paramasivam Nagarajan, Fitzgerald Donnacha, Seidel Maximilian, Esposito Irene, Germing Ulrich, Cadeddu Ron-Patrick, Nachtkamp Kathrin, Jäger Paul, Ulrych Thomas, Fischer Johannes C, Rox Jutta M, Giesel Frederik, Koch Raphael, Antoch Gerald, Distler Jörg H W, Meuth Sven G, Jacobsen Malte, Hübschmann Daniel, Lu Junyan, Iaccarino Ingram, Haas Simon, Damm Frederik, Dietrich Sascha

Abstract excerpt

The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. The PTCL had a clonal T-cell receptor rearrangement, which was already detectable in the apheresis product for CAR T-cell manufacturing and 7 months...

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Identifiers

PMID: 39589371
DOI: 10.1056/NEJMoa2402730

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